Stem Cells International / 2017 / Article / Tab 1

Review Article

Noncoding RNA and Cardiomyocyte Proliferation

Table 1

A summary of the effect of miRNAs on neonatal and adult cardiomyocyte proliferation analyzed with different methodologies.

MicroRNAsmiR-499miR-410/mi-R495miR-590/miR-199amiR-204miR-195 (miR15 family)miR-34amiR17-92 clustermiR-17-3pmiR-222miR302-367miR-29amiR-133miR-1
SpeciesMiceMiceMiceMiceMiceMiceMiceMiceMiceMiceMiceMice and zebrafishMice
ExperimentIn vitro:
neonatal CMs
Mouse P19CL6 cells
In vitro: neonatal cmsIn vivo: neonatal adultIn vitro: neonatal cms and adult cms
In vivo: adult miRNA-204 transgenic mice
In vivo: transgenic miceIn vitro: neonatal cms
In vivo: neonatal mi and adult mi
In vivo: transgenic miceIn vitro: NRVMs
In vivo: adult myocardial ischemia-reperfusion injury
In vitro: NRVMs
In vivo: exercise model
In vitro: transgenic mice and adult mice treated with miRNA mimics for mir302-367In vitro: neonatal cmsIn vivo: transgenic miceIn vivo: transgenic mice
Methods and fold changesEdU (~1.5-fold)EdU (~2.5-fold)
Ki-67 (~3 fold)
EdU (~3-fold)EdU (NRVMs) ~8-fold
Aurora B (NRWMs) ~2-fold
NRVMs numbers:~1.2-fold
ARVM numbers: ~1.2-fold
PH3 (transgenic mice): ~3-fold
PH3: ~2-foldPH3: neonatal MI ~3-fold
Adult MI ~8-fold
EdU: NRVMs ~3-fold
Adult: CM numbers ~3-fold
PH3 ~3-fold
EdU: ~1.5-fold
K-i67: ~2.3-fold
Cell number: ~1.2-fold
EdU: ~4-fold
Ki-67:~3-fold
Cell number: ~1.2-fold
Adult: CM number ~1.6-fold
Neonatal: pH 3 ~6-fold
Embryonic: pH 3 ~4-fold
Ki-67(~3-fold)
PH3 (~3-fold)
PH3: ~2-foldPH3: ~4-fold
CM numbers: ~1.2-fold
EffectPromotePromotePromotePromoteSuppressSuppressPromotePromotePromotePromoteSuppressSuppressSuppress
Target genesSox6 and Cyclin D1Cited2HOMER1, HOPX, and CLIC5Jarid2Check1PNUTs, SRT1, Bcl2, Cyclin D1, and Sirt1PTENTIMP-3
PTEN
P27, HMBOX1, HIPK-1, and HIK-2Mst1, Lats2, and Mob1bCyclin D2, Akt3, and CDK2CRF and Cyclin D2Hand2 and SRF
StageNeonatalNeonatalNeonatal and adultNeonatal and adultNeonatal and adultNeonatal and adultEmbryonic and neonatal adultNeonatalNeonatalEmbryonic and neonatal AdultNeonatalNeonatalAdult
Reference[11, 12][14][8][20][27, 28][26][21][22][15][23, 24][19][16, 17][29]

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