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| MicroRNAs | miR-499 | miR-410/mi-R495 | miR-590/miR-199a | miR-204 | miR-195 (miR15 family) | miR-34a | miR17-92 cluster | miR-17-3p | miR-222 | miR302-367 | miR-29a | miR-133 | miR-1 |
| Species | Mice | Mice | Mice | Mice | Mice | Mice | Mice | Mice | Mice | Mice | Mice | Mice and zebrafish | Mice |
| Experiment | In vitro:
neonatal CMs
Mouse P19CL6 cells | In vitro: neonatal cms | In vivo: neonatal adult | In vitro: neonatal cms and adult cms
In vivo: adult miRNA-204 transgenic mice | In vivo: transgenic mice | In vitro: neonatal cms
In vivo: neonatal mi and adult mi | In vivo: transgenic mice | In vitro: NRVMs
In vivo: adult myocardial ischemia-reperfusion injury | In vitro: NRVMs
In vivo: exercise model | In vitro: transgenic mice and adult mice treated with miRNA mimics for mir302-367 | In vitro: neonatal cms | In vivo: transgenic mice | In vivo: transgenic mice |
| Methods and fold changes | EdU (~1.5-fold) | EdU (~2.5-fold)
Ki-67 (~3 fold) | EdU (~3-fold) | EdU (NRVMs) ~8-fold
Aurora B (NRWMs) ~2-fold
NRVMs numbers:~1.2-fold
ARVM numbers: ~1.2-fold
PH3 (transgenic mice): ~3-fold | PH3: ~2-fold | PH3: neonatal MI ~3-fold
Adult MI ~8-fold
EdU: NRVMs ~3-fold | Adult: CM numbers ~3-fold
PH3 ~3-fold | EdU: ~1.5-fold
K-i67: ~2.3-fold
Cell number: ~1.2-fold | EdU: ~4-fold
Ki-67:~3-fold
Cell number: ~1.2-fold | Adult: CM number ~1.6-fold
Neonatal: pH 3 ~6-fold
Embryonic: pH 3 ~4-fold | Ki-67(~3-fold)
PH3 (~3-fold) | PH3: ~2-fold | PH3: ~4-fold
CM numbers: ~1.2-fold |
| Effect | Promote | Promote | Promote | Promote | Suppress | Suppress | Promote | Promote | Promote | Promote | Suppress | Suppress | Suppress |
| Target genes | Sox6 and Cyclin D1 | Cited2 | HOMER1, HOPX, and CLIC5 | Jarid2 | Check1 | PNUTs, SRT1, Bcl2, Cyclin D1, and Sirt1 | PTEN | TIMP-3
PTEN | P27, HMBOX1, HIPK-1, and HIK-2 | Mst1, Lats2, and Mob1b | Cyclin D2, Akt3, and CDK2 | CRF and Cyclin D2 | Hand2 and SRF |
| Stage | Neonatal | Neonatal | Neonatal and adult | Neonatal and adult | Neonatal and adult | Neonatal and adult | Embryonic and neonatal adult | Neonatal | Neonatal | Embryonic and neonatal Adult | Neonatal | Neonatal | Adult |
| Reference | [11, 12] | [14] | [8] | [20] | [27, 28] | [26] | [21] | [22] | [15] | [23, 24] | [19] | [16, 17] | [29] |
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