Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Table 1

Authors	TNT donor cells	TNT receiver cells	Transported cargoes	References
Onfelt et al. (2004)	Human NK cells	Human EBV-transformed human B cells	GFP-tagged cell surface class I MHC	[2]
	Human macrophages	Same cells
	Human EBV-transformed human B cells	Same cells
	Murine J774 macrophages	Same cells
Rustom et al. (2004)	Rat pheochromocytoma PC12	Same cells	Microvesicles	[1]
	Human embryonic kidney (HEK)	Same cells	Organelles
	Normal rat kidney (NRK)	Same cells
Castro et al. (2005)	Colon carcinoma cell line SW620	Same cells	ND	[41]
Koyanagi et al. (2005)	Human endothelial progenitor (EPC)	Neonatal rat cardiomyocytes (CM)	Mitochondria	[16]
Watkins et al. (2005)	Human dendritic cells	Same cells and THP-1 cells	Calcium flux	[23]
	Human THP-1 monocytes	Same cells	Major histocompatibility proteins (MHC class I)
Chinnery et al. (2008)	Murine MHC class II dendritic cells	Same cells	ND	[21]
Gurke et al. (2008)	Normal rat kidney cells (NRK)	Same cells	Endocytic organelles	[13]
Onfelt et al. (2006)	Human macrophages	Same cells	Bacteria	[28]
			Mitochondria
			Vesicles (endosomes, lysosomes)
Sowinski et al. (2008)	Jurkat T cells	Same cells and primary T cells	HIV viral particles	[57]
	Primary T cells	Same cells
Bukoreshtliev et al. (2009)	PC12 cells	PC12 cells	Intracellular organelle transfer	[11]
Eugenin et al. (2009)	Human macrophages	Same cells	HIV viral particles	[58]
Plotnikov et al. (2010)	Human mesenchymal multipotent stromal cells (MMSC)	Rat renal tubular cells (RTC)	Mitochondria	[29]
Acquistapace et al. (2011)	Human mesenchymal stem cells (MSCs)	Cardiomyocytes	Mitochondria and intracellular material	[30]
Domhan et al. (2011)	Human proximal tubular epithelial cells (RPTEC)	Same cells	Microvesicles	[12]
Wang et al. (2011)	Rat hippocampal astrocytes	Same cells and rat hippocampal neurons	Endoplasmic reticulum	[49]
	Rat hippocampal neurons	Same cells and rat hippocampal astrocytes	Mitochondria
			Golgi fragments
			Endosomes
			Amyloid β
Yasuda et al. (2011)	Human umbilical vein endothelial cells (HUVEC)	Stressed HUVEC	Lysosomes	[15]
			Mitochondria
Islam et al. (2012)	Murine MSCs	Murine alveoli	Mitochondria	[32]
Lou et al. (2012)	Human primary cancer cells	Same cells	Mitochondria	[39]
	Human mesothelial lines (MSTO-211H, VAMT, H-Meso)	Same cells
Schiller et al. 2012	HeLa	Same cells	Transmembrane HLA-A2-EGFP protein	[43]
Vallabhaneni et al. (2012)	Human MSCs	Human vascular smooth muscle cells (VSMCs)	Mitochondria	[9]
Wittig et al. (2012)	Human retinal pigment epithelial (ARP-19) cells	Same cells		[14]
Costanzo et al. (2013)	CAD cells	Same cells and with transfected CADs	Htt aggregates	[26]
	Primary cerebellar granule neurons (CGNs)	Same cells and with transfected CGNs
Pasquier et al. (2013)	Human mesenchymal stem cells (MSCs)	Same cells and ovarian and cancer cell lines	Mitochondria	[36]
	Human endothelial cells (HECs)	Same cells and ovarian and cancer cell lines
	Human ovarian cancer cells (SKOV3, OVCAR3, HTB-161)	Same cells
	Human breast cancer cells (MDA-MB231 and MCF7)	Same cells
Rainy et al. (2013)	Human B cells	Human T cells	Plasma membrane-associatedproteins (H-Ras)	[27]
Ady et al. (2014)	VAMT (sarcomatoid mesothelioma cell line)	Same cells	ND	[38]
	H2052 (mesothelioma cell line)	Same cells
	MSTO-211H (derived from mesothelioma patient)	Same cells
	Met5A (immortalized mesothelioma cell line)	Same cells
Ahmad et al. (2014)	Murine MSCs	Murine lung epithelial cells	Mitochondria	[31]
Liu et al. (2014)	Human MSCs	Human umbilical vein endothelial cell (HUVEC)	Mitochondria	[34]
Thayanithy et al. (2014)	Murine osteosarcoma K7M2 cells	Same cells and MC3T3 murine osteoblasts	MicroRNAs (miR-199a)	[37]
	SKOV3 ovarian cancer cells	Nonmalignant ovarian epithelial cells
Thayanithy et al. (2014)	Human biphasic mesothelioma MSTO-211H cells	Same cells	Exosomes from other cells	[40]
Biran et al. (2015)	Oncogene or DNA damage-induced senescent cells	NK cells	Proteins	[10]
Burtey et al. (2015)	HeLa	NRK fibroblasts	Tf-R (transferrin receptor), endosomes	[44]
Caicedo et al. (2015)	Human mesenchymal stem cells (MSCs)	Human breast cancer cell line MDA-MB-231	Mitochondria	[35]
Polak et al. (2015)	Bidirectional: human MSCs to human acute lymphoblastic leukemia cells (BCP-ALL cell line); Bidirectional: human MSCs to human B cell precursor of Leukemia Nalm6 (B-Other); Bidirectional: human MSCs to human acute lymphoblastic leukemia cells (TEL-AML1)		ND	[47]
Wang and Gerdes (2015)	PC12 cells (−/+ultraviolet light treatment)	PC12 cells (−/+ultraviolet light treatment)	Mitochondria	[8]
Zhu et al. (2015)	CAD neuronal cells	Same cells	Prions	[54]
			Lysosomes
			Early endosomes
Hashimoto et al. (2016)	Monocyte-derived macrophages	Same cells	HIV-1	[56]
Hayakawa et al. (2016)	Astrocytes	Neurons	Mitochondria	[115]
Jackson et al. (2016)	Human MSCs	Human monocyte-derived macrophages	Mitochondria	[33]
		Murine alveolar macrophages
Lu et al. (2016)	Bladder cancer cells	Same cells	Mitochondria	[46]
Moschoi et al. (2016)	BM-MSCs	Acute myeloid leukemia cells	Mitochondria	[48]
Tardivel et al. (2016)	Neurons	Neurons	Tau protein	[7]
Victoria et al. (2016)	Astrocytes	Neurons	Prions	[55]
Zhang et al. (2016)	iPSC-MSCs and BM-MSCs	Cardiomyocytes	Mitochondria	[62]