Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells

<div>Differentiation capacity of iPSC-MSCs after Kindlin-2 transfection. Osteogenic, chondrogenic, and adipogenic differentiation potential of hiPSC-MSCs after transfection with constructs modulating Kindlin-2. Alizarin Red staining for mineralized deposits (a), Alcian Blue staining for chondrocyte pellets (b), and Oil Red-O staining for lipid formation (c) formed by the three iPSC-MSC cell lines. The mRNA expression level of the relative expression of genes associated with osteogenesis (osteocalcin and alkaline phosphatase), chondrogenesis (collagen type II and aggrecan), and adipogenesis (PPAR-<i>γ</i> and LPL). The data represent the mean expression values normalized to the housekeeping gene GAPDH. 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Stem Cells International

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Figure 4

Figure 4: Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells 