Cardiac Progenitor Cells and the Interplay with Their Microenvironment

Figure 2

The CPC microenvironments. For therapeutic application, CPCs can be isolated from their resident niche and (a) cultured in an in vitro niche, prior to transplantation into the infarcted heart, or (b) the local microenvironment can be modulated in order to recruit CPCs to the injured area. The aim of both approaches is to regenerate the myocardium thanks to CPC proliferation and differentiation into cardiomyocytes.