Involvement of WNT Signaling in the Regulation of Gestational Age-Dependent Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation

Table 3

Pathway analysis of differentially expressed genes between preterm and term UC-MSCs.

Pathway	value	Matched; entities	Pathway entities
Hs_Interferon_alpha-beta_signaling_WP1835_83224	1.91E−09	29	122
Hs_GPCR_downstream_signaling_WP1824_83301	1.85E−07	171	919
Hs_Interferon_gamma_signaling_WP1836_83234	8.41E−06	32	170
Hs_NRF2_pathway_WP2884_83041	3.20E−05	36	143
Hs_Immunoregulatory_interactions_between_a_Lymphoid_and_a_non-Lymphoid_cell_WP1829_83164	5.33E−05	32	332
Hs_Gastrin-CREB_signalling_pathway_via_PKC_and_MAPK_WP2664_83266	1.55E−04	42	180
Hs_Focal_Adhesion_WP306_80308	2.25E−04	45	191
Hs_GPCR_ligand_binding_WP1825_83346	2.99E−04	85	438
Hs_Regulation_of_beta-cell_development_WP3513_83407	3.98E−04	11	28
Hs_Glycerophospholipid_biosynthesis_WP2740_83341	4.59E−04	26	96
Hs_Allograft_Rejection_WP2328_78554	5.49E−04	24	100
Hs_Extracellular_matrix_organization_WP2703_83106	6.47E−04	22	78
Hs_Selenium_Micronutrient_Network_WP15_82705	6.56E−04	23	84
MAPK signaling pathway	7.53E−04	55	257
Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_75258	7.89E−04	23	104
Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974	8.29E−04	29	114
Hs_Parkin-Ubiquitin_Proteasomal_System_pathway_WP2359_72121	9.16E−04	20	73
Hs_Cell_surface_interactions_at_the_vascular_wall_WP1794_83824	0.0010894155	25	99
Hs_BDNF_signaling_pathway_WP2380_79953	0.0012996251	34	144
Hs_Nuclear_Receptors_Meta-Pathway_WP2882_83040	0.0013138579	62	318
Hs_Wnt_Signaling_Pathway_WP428_79854	0.0013306512	19	67
Hs_B_Cell_Receptor_Signaling_Pathway_WP23_79985	0.0014992601	25	98
Hs_MAPK_Signaling_Pathway_WP382_79951	0.0016350249	38	168
Hs_SIDS_Susceptibility_Pathways_WP706_80056	0.0017464098	37	166
Hs_O-linked_glycosylation_WP3315_83262	0.0020349505	25	104
Hs_NGF_signalling_via_TRKA_from_the_plasma_membrane_WP1873_83147	0.0023317037	20	77
Hs_Arachidonic_acid_metabolism_WP2650_83044	0.0026565776	15	53
Hs_Vitamin_B12_Metabolism_WP1533_82707	0.0026565776	15	53
Hs_Folate_Metabolism_WP176_82704	0.0028243104	18	67
Hs_Nanoparticle-mediated_activation_of_receptor_signaling_WP2643_74251	0.0033263897	10	28
Hs_Muscle_contraction_WP1864_83290	0.0033954314	17	63
Hs_NCAM_signaling_for_neurite_out-growth_WP1866_83314	0.0033983262	12	40
Hs_Corticotropin-releasing_hormone_WP2355_79973	0.0034443145	23	92
Hs_Cori_Cycle_WP1946_79691	0.0037244426	7	23
Hs_Eicosanoid_Synthesis_WP167_82702	0.0037961914	8	25
Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010	0.0037961914	8	20
Hs_Semaphorin_interactions_WP1907_83271	0.0040335725	18	67
Hs_Histidine,_lysine,_phenylalanine,_tyrosine,_proline_and_tryptophan_catabolism_WP3573_83463	0.005489827	12	39
Hs_ACE_Inhibitor_Pathway_WP554_77712	0.0055746404	7	17
Hs_Integrin-mediated_Cell_Adhesion_WP185_80036	0.005693194	24	101
Hs_Prostaglandin_Synthesis_and_Regulation_WP98_72088	0.0058502043	10	31
Hs_GPCRs,_Class_A_Rhodopsin-like_WP455_81793	0.0062826765	50	262
Hs_Phase_1_-_Functionalization_of_compounds_WP1879_83057	0.0067225243	21	88
Hs_Complement_and_Coagulation_Cascades_WP558_79680	0.007009079	16	61
Hs_Lipid_digestion,_mobilization,_and_transport_WP2764_83187	0.0071218973	15	61
Hs_Type_II_diabetes_mellitus_WP1584_81779	0.0074452385	8	22
Hs_miRNA_targets_in_ECM_and_membrane_receptors_WP2911_83020	0.0074452385	8	45
Hs_Insulin_Signaling_WP481_82731	0.0084877005	34	161
Hs_L1CAM_interactions_WP1843_83082	0.008832967	21	92
Hs_Calcium_Regulation_in_the_Cardiac_Cell_WP536_80211	0.008975188	32	150
Hs_Cell_junction_organization_WP1793_83402	0.009355909	20	85
Hs_XBP1(S)_activates_chaperone_genes_WP3472_83243	0.010727612	22	98
Hs_G1_to_S_cell_cycle_control_WP45_80001	0.010931775	17	68
Hs_Prostate_Cancer_WP2263_80439	0.011036183	25	117
Hs_Wnt_Signaling_Pathway_and_Pluripotency_WP399_79474	0.011321301	23	101
Hs_Human_Complement_System_WP2806_83005	0.011321301	23	136
Hs_Assembly_of_collagen_fibrils_and_other_multimeric_structures_WP2798_83231	0.0113662705	9	29
Hs_DSCAM_interactions_WP1808_83372	0.0118092755	5	11
Hs_Arrhythmogenic_Right_Ventricular_Cardiomyopathy_WP2118_71265	0.012006286	18	78
Hs_Endothelin_Pathways_WP2197_74852	0.0121577475	10	33
Hs_Nuclear_Receptors_WP170_71083	0.012546546	11	38
Hs_Metapathway_biotransformation_WP702_73516	0.013431928	34	188
Hs_Potassium_Channels_WP2669_83272	0.0139101725	15	59
Hs_Myometrial_Relaxation_and_Contraction_Pathways_WP289_81078	0.014395579	32	156
Hs_Collagen_biosynthesis_and_modifying_enzymes_WP2725_83130	0.014458477	14	54
Hs_Cardiac_Hypertrophic_Response_WP2795_78544	0.014458477	14	54
Hs_IL-3_Signaling_Pathway_WP286_78583	0.014911717	13	49
Hs_Hematopoietic_Stem_Cell_Differentiation_WP2849_83039	0.015318828	11	98
Hs_Telomere_Maintenance_WP1928_83097	0.016210536	15	61
Hs_Signaling_Pathways_in_Glioblastoma_WP2261_81197	0.016799	19	83
Glycolysis/Gluconeogenesis	0.017775405	16	66
Hs_Reversible_hydration_of_carbon_dioxide_WP2770_83176	0.017944276	5	12
Hs_Transport_of_inorganic_cations-anions_and_amino_acids-oligopeptides_WP1936_83267	0.01851932	21	97
Hs_Neural_Crest_Differentiation_WP2064_79263	0.01922032	22	101
Hs_Signaling_by_the_B_Cell_Receptor_(BCR)_WP2746_83158	0.020346014	24	247
Hs_Adipogenesis_WP236_80209	0.02145827	27	131
Hs_Secretion_of_Hydrochloric_Acid_in_Parietal_Cells_WP2597_78485	0.021901488	3	5
Pathways in cancer	0.023056423	59	327
Hs_NLR_Proteins_WP288_80026	0.02675793	4	10
Hs_Neurotransmitter_Release_Cycle_WP1871_83254	0.027170882	10	39
Hs_Transport_of_vitamins,_nucleosides,_and_related_molecules_WP1937_83207	0.027170882	10	38
Hs_S_Phase_WP2772_83395	0.02769413	25	123
Hs_Integrin_cell_surface_interactions_WP1833_83181	0.028421601	15	66
Hs_GABA_synthesis,_release,_reuptake_and_degradation_WP2685_83090	0.030757299	6	19
Hs_Transport_of_glucose_and_other_sugars,_bile_salts_and_organic_acids,_metal_ions_and_amine_compounds_WP1935_83132	0.0316663	21	100
Hs_Class_I_MHC_mediated_antigen_processing_&_presentation_WP3577_83467	0.032386538	49	330
Hs_Formation_of_Fibrin_Clot_(Clotting_Cascade)_WP1818_83143	0.032393858	10	39
Hs_Parkinsons_Disease_Pathway_WP2371_79766	0.032393858	10	71
Hs_ErbB_Signaling_Pathway_WP673_80202	0.032395784	13	55
Hs_Interferon_type_I_signaling_pathways_WP585_80201	0.032395784	13	54
Hs_Metabolism_of_water-soluble_vitamins_and_cofactors_WP1857_83083	0.033578653	19	93
Hs_Primary_Focal_Segmental_Glomerulosclerosis_FSGS_WP2572_79947	0.033947315	16	74
Hs_Glycolysis_and_Gluconeogenesis_WP534_78585	0.034427498	12	49
Hs_Interleukin-11_Signaling_Pathway_WP2332_79525	0.03641972	11	44
Hs_Sleep_regulation_WP3591_83861	0.0382818	10	39
Hs_Regulation_of_toll-like_receptor_signaling_pathway_WP1449_81172	0.03940498	27	149
Hs_PI_Metabolism_WP2747_83160	0.03972961	12	51
Hs_Signal_regulatory_protein_(SIRP)_family_interactions_WP1909_83190	0.0397491	4	11
Hs_Neurotoxicity_of_clostridium_toxins_WP2665_83321	0.0397491	4	22
Hs_Overview_of_nanoparticle_effects_WP3287_82926	0.039779507	6	22
Hs_Protein_folding_WP1892_83103	0.039869573	9	34
Hs_Platelet_homeostasis_WP1885_83192	0.041275427	15	70
Hs_Synthesis_of_DNA_WP1925_83144	0.04189585	20	98
Hs_Pathogenic_Escherichia_coli_infection_WP2272_78594	0.042428713	13	64
Hs_Mitotic_G1-G1-S_phases_WP1858_83315	0.042929105	25	128
Hs_Synaptic_Vesicle_Pathway_WP2267_78595	0.04557775	12	51
Hs_Spinal_Cord_Injury_WP2431_80343	0.046727844	23	117
Hs_Gamma_carboxylation,_hypusine_formation_and_arylsulfatase_activation_WP2762_83388	0.04724196	9	36
Hs_RAF-MAP_kinase_cascade_WP2735_83142	0.047904383	36	216
Hs_Binding_and_Uptake_of_Ligands_by_Scavenger_Receptors_WP2784_83217	0.048846867	11	195
Hs_Extracellular_vesicle-mediated_signaling_in_recipient_cells_WP2870_79555	0.04923168	8	30