Research Article

Intra-Articular Injection of Human Synovial Membrane-Derived Mesenchymal Stem Cells in Murine Collagen-Induced Arthritis: Assessment of Immunomodulatory Capacity In Vivo

Figure 5

SM-MSCs favored the development of regulatory B cells in the spleen. (a) Surface expression of CD21 and CD23 on B220+ gated B cells derived from mice treated or not treated with SM-MSCs ( per group). The proportions of T2 (CD21hiCD23hi), FO (CD21intCD23int), and MZ (CD23lowCD21hi) cells were analyzed by flow cytometry. (b) Splenocytes were stimulated with PMA/ionomycin for 4 h and analyzed for the frequency of B10 (CD19+CD5+CD1d+IL-10+) cells in mice. Data have been presented as meanSD values. .
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