Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models

Figure 3

SC recordings from RD nude rats with retinal sheet transplants. (a) Spike count totals (heat maps) over the entirety of the region recorded in SC for all transplanted rats. L: laminated transplant; R: rosetted transplant; D: disorganized transplant. Responses were observed only in certain areas in the SC and were centered on a peak. Sample traces from areas (marked with X) with robust, intermediate, and no response for (b) transplant number 5 with strong responses and (c) transplant number 1 with weak responses. Arrows and black bars indicate the light stimulus. Taken from Figure 7 of Seiler et al., vision recovery and connectivity by fetal retinal sheet transplantation in an immunodeficient retinal degenerate rat model; IOVS 2017;58:614–630. DOI:10.1167/iovs.15-19028; licensed under the Creative Commons attribution license.