Review Article

The Effects of Different Factors on the Behavior of Neural Stem Cells

Table 2

Effects of microRNAs on the proliferation and differentiation of NSCs.

MicroRNAThe role of proliferationThe role of differentiationMechanism

miR-34a [75]Postmitotic neurons ↑Neurite elongation ↑miR-34a ↑ → SIRT1 ↓ → P53 acetylation ↑
miR-125b [77]BrdU-positive cells ↓Nestin-positive cells ↓;
Sox2-positive cells ↓;
vimentin-positive cells ↓;
MAP2-positive cells ↑;
Tuj1-positive cells ↑;
cell migration ↑
miR-125b ↑ → nestin ↓
miR-146 [81]Neural sphere diameter ↓β-Tubulin III positive cells ↓;
GFAP-positive cells ↑
miR-146 ↑ → Notch1 ↓
miR-342-5p [82]BrdU-positive cells ↓PAX6-positive cells ↓;
TBR2-positive cells ↑;
GFAP-positive cells ↓
Notch → Hes5 ↓ → miR-342-5p ↑ → GFAP ↓
miR-184 [84]BrdU-positive cells ↑Tuj1-positive cells ↓;
GFAP-positive cells ↓
MBD1 ↓ → miR-184 ↑ → Numbl ↑
miR-9 [85]BrdU-positive cells ↓Tuj1-positive cells ↑;
GFAP-positive cells ↑
miR-9 ↑ → TLX ↓ → proliferation ↓, neurons ↑
miR-7 [86]G1/S cell cycle arrestTuj1-positive cells ↑;
MAP2-positive cells ↑;
Nestin-positive cells ↓;
vimentin-positive cells ↓
miR-7 ↑ → Klf4 ↓ → proliferation ↓, neurons ↑
miR-124 [87, 88]BrdU-positive cells ↓Tuj1-positive cells ↑;
NeuN-positive cells ↑;
GFAP-positive cells ↓
miR-124 ↑ → TrkB ↑,Cdc42 ↑ → neurons ↑