Review Article
The Effects of Different Factors on the Behavior of Neural Stem Cells
Table 2
Effects of microRNAs on the proliferation and differentiation of NSCs.
| MicroRNA | The role of proliferation | The role of differentiation | Mechanism |
| miR-34a [75] | Postmitotic neurons ↑ | Neurite elongation ↑ | miR-34a ↑ → SIRT1 ↓ → P53 acetylation ↑ | miR-125b [77] | BrdU-positive cells ↓ | Nestin-positive cells ↓; Sox2-positive cells ↓; vimentin-positive cells ↓; MAP2-positive cells ↑; Tuj1-positive cells ↑; cell migration ↑ | miR-125b ↑ → nestin ↓ | miR-146 [81] | Neural sphere diameter ↓ | β-Tubulin III positive cells ↓; GFAP-positive cells ↑ | miR-146 ↑ → Notch1 ↓ | miR-342-5p [82] | BrdU-positive cells ↓ | PAX6-positive cells ↓; TBR2-positive cells ↑; GFAP-positive cells ↓ | Notch → Hes5 ↓ → miR-342-5p ↑ → GFAP ↓ | miR-184 [84] | BrdU-positive cells ↑ | Tuj1-positive cells ↓; GFAP-positive cells ↓ | MBD1 ↓ → miR-184 ↑ → Numbl ↑ | miR-9 [85] | BrdU-positive cells ↓ | Tuj1-positive cells ↑; GFAP-positive cells ↑ | miR-9 ↑ → TLX ↓ → proliferation ↓, neurons ↑ | miR-7 [86] | G1/S cell cycle arrest | Tuj1-positive cells ↑; MAP2-positive cells ↑; Nestin-positive cells ↓; vimentin-positive cells ↓ | miR-7 ↑ → Klf4 ↓ → proliferation ↓, neurons ↑ | miR-124 [87, 88] | BrdU-positive cells ↓ | Tuj1-positive cells ↑; NeuN-positive cells ↑; GFAP-positive cells ↓ | miR-124 ↑ → TrkB ↑,Cdc42 ↑ → neurons ↑ |
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