Paracrine Potential of the Human Adipose Tissue-Derived Stem Cells to Modulate Balance between Matrix Metalloproteinases and Their Inhibitors in the Osteoarthritic Cartilage In Vitro

Figure 5

Total activity of MMPs (including MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, and MMP-14) in supernatants of cartilage explants (CE), adipose tissue-derived stem cells (ASC), and in cocultures (CE + ASC) on day 7. After 2 h of incubation, fluorescence signal was measured at Ex/Em = 490/520 nm. IM + PP—IM supplemented with human platelet growth factor-enriched plasma (PP), IL-1β—interleukin-1β. Data presented as mean ± standard deviation, , .