Review Article

Therapeutic Potential of Stem Cells in Follicle Regeneration

Table 3

Current studies of stem cell use registered on ClinicalTrials.gov [122].

NumberStudyKind of stem cellsMethodConditionsStatusTrial institution/sponsor and countryNCT number and duration period

1“Stem Cell Educator Therapy in Alopecia Areata”Cord blood-derived multipotent stem cells (CB-SCs)A closed loop system that circulates a patient’s blood through a blood cell separator, briefly cocultures the patient’s lymphocytes with adherent CB-SCs in vitro, and returns the educated lymphocytes (but not the CB-SCs) to the patient’s circulationAlopecia areataUKNThe First Hospital of Hebei Medical University Shijiazhuang, Hebei, ChinaNCT01673789 2012-2013
2“The Effect of Allogeneic Human Adipose Derived Stem Cell Component Extract on Androgenic Alopecia”Allogeneic human ADSC component extractApplying 1.2 g of allogeneic human adipose-derived stem cell component extract on their scalp for 16 weeksAndrogenic alopeciaCompletedPusan National University Hospital, South KoreaNCT02594046 2015–2017
3“Adipose Tissue Derived Stem Cell Based Hair Restoration Therapy for Androgenetic Alopecia”Autologous MSC and human platelet-rich plasmaMSCs derived from adipose tissue with human platelet-rich plasma will be appliedAndrogenic alopeciaNot yet recruitingKing Edward Medical University, PakistanNCT02865421
4“Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata”High-density platelet-rich plasma and adipose-derived tissue stromal vascular fraction (AD-tSVF)Use of high-density platelet-rich plasma concentrates and cell-enriched emulsified adipose-derived tissue stromal vascular fraction (AD-tSVF) via intravenous infusionAlopecia areata, scarring alopeciaRecruitingRegeneris Medical, Global Alliance for Regenerative Medicine, Healeon Medical Inc., USANCT03078686 2017–2019
5“AGA Biocellular Stem/Stromal Hair Regenerative Study”Adipose-derived tissue stromal vascular fraction (AD-tSVF) and high-density platelet-rich plasmaBiocellular mixture of emulsified AD-tSVF and high-density platelet-rich plasma concentrate (HD-PRP) as compared with adipose-derived cell-enriched SVF (AD-cSVF)+AD-tSVF and HD-PRP using Healeon Centricyte 1000 system and intradermal injectionsAndrogenetic alopecia, female pattern hair lossRecruitingHealeon Medical Inc., Ministry of Health, Honduras Irvine, California, USANCT02849470 2016–2018
6“Point-of-Care Adipose-derived Cells for Hair Growth”Stromal vascular fraction (SVF) cellsA single injection into the scalp of autologous adipose-derived SVF cellsAndrogenic alopeciaRecruitingUniversity of Florida Gainesville, Florida, USANCT02729415 2016-2017