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Stem Cells International
Volume 2018 (2018), Article ID 1241323, 14 pages
https://doi.org/10.1155/2018/1241323
Research Article

IFNα-Expressing Amniotic Fluid-Derived Mesenchymal Stem Cells Migrate to and Suppress HeLa Cell-Derived Tumors in a Mouse Model

1The First Affiliated Hospital of Harbin Medical University, Harbin, China
2The Third Affiliated Hospital of Harbin Medical University, Harbin, China

Correspondence should be addressed to Guangmei Zhang; moc.621@4102gnahziemgnaug

Received 16 October 2017; Accepted 23 January 2018; Published 2 April 2018

Academic Editor: Atique Ahmed

Copyright © 2018 Jun Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Peralta-Zaragoza, V. H. Bermudez-Morales, C. Perez-Plasencia, J. Salazar-Leon, C. Gomez-Ceron, and V. Madrid-Marina, “Targeted treatments for cervical cancer: a review,” OncoTargets and Therapy, vol. 5, pp. 315–328, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Lembo, M. Donalisio, M. De Andrea et al., “A cell-based high-throughput assay for screening inhibitors of human papillomavirus-16 long control region activity,” The FASEB Journal, vol. 20, no. 1, pp. 148–150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Hall and F. M. MA, “The participation of mesenchymal stem cells in tumor stroma formation and their application as targeted-gene delivery vehicles,” in Handbook of Experimental Pharmacology, vol. 180, pp. 263–283, Springer, Berlin, Heidelberg, 2007. View at Publisher · View at Google Scholar
  4. J. J. Nan Chen and X. Li, “Research progress of targeted therapy for cervical cancer,” Chinese Journal of Clinical Obstetrics and Gynecology, vol. 11, no. 1, pp. 68–70, 2010. View at Google Scholar
  5. J. X. Raudel Sandoval, M. Pilkinton, D. Salvi, H. Kiyokawa, and O. R. Colamonici, “Different requirements for the cytostatic and apoptotic effects of type I interferons: induction of apoptosis requires ARF but not p53 in osteosarcoma cell lines,” Journal of Biological Chemistry, vol. 279, no. 31, pp. 32275–32280, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Einhorn and D. Grandér, “Why do so many cancer patients fail to respond to interferon therapy,” Journal of Interferon & Cytokine Research, vol. 16, no. 4, pp. 275–281, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Dominici, K. Le Blanc, I. Mueller et al., “Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement,” Cytotherapy, vol. 8, no. 4, pp. 315–317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Antonucci, L. Stuppia, Y. Kaneko et al., “Amniotic fluid as a rich source of mesenchymal stromal cells for transplantation therapy,” Cell Transplantation, vol. 20, no. 6, pp. 789–796, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Hu, L.-J. Yang, H. Liu et al., “Fractional cultivation, identification and immunosuppression of amniotic fluid-derived human mesenchymal stem cells,” Bulletin of the Academy of Military Medical Sciences, vol. 33, no. 2, 2009. View at Google Scholar
  10. S.-C. Hung, W.-P. Deng, W. K. Yang et al., “Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging,” Clinical Cancer Research, vol. 11, no. 21, pp. 7749–7756, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Komarova, Y. Kawakami, M. A. Stoff-Khalili, D. T. Curiel, and L. Pereboeva, “Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses,” Molecular cancer therapeutics, vol. 5, no. 3, pp. 755–766, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Kidd, L. Caldwell, M. Dietrich et al., “Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment,” Cytotherapy, vol. 12, no. 5, pp. 615–625, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Bitsika, M. G. Roubelakis, D. Zagoura et al., “Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer,” Stem Cells and Development, vol. 21, no. 7, pp. 1097–1111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Nakamizo, F. Marini, T. Amano et al., “Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas,” Cancer Research, vol. 65, no. 8, pp. 3307–3318, 2005. View at Publisher · View at Google Scholar
  15. K. Nakamura, Y. Ito, Y. Kawano et al., “Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model,” Gene Therapy, vol. 11, no. 14, pp. 1155–1164, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. R. S. Rachakatla, F. Marini, M. L. Weiss, M. Tamura, and D. Troyer, “Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors,” Cancer Gene Therapy, vol. 14, no. 10, pp. 828–835, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. N. H. Kang, K. A. Hwang, S. U. Kim et al., “Potential antitumor therapeutic strategies of human amniotic membrane and amniotic fluid-derived stem cells,” Cancer Gene Therapy, vol. 19, no. 8, pp. 517–522, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Djouad, P. Plence, C. Bony et al., “Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals,” Blood, vol. 102, no. 10, pp. 3837–3844, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Sessarego, A. Parodi, M. Podesta et al., “Multipotent mesenchymal stromal cells from amniotic fluid: solid perspectives for clinical application,” Haematologica, vol. 93, no. 3, pp. 339–346, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Rennie, A. Gruslin, M. Hengstschläger et al., “Applications of amniotic membrane and fluid in stem cell biology and regenerative medicine,” Stem Cells International, vol. 2012, Article ID 721538, 13 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Weber, M. Y. Emmert, L. Behr et al., “Prenatally engineered autologous amniotic fluid stem cell-based heart valves in the fetal circulation,” Biomaterials, vol. 33, no. 16, pp. 4031–4043, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Djouad, D. Mrugala, D. Noël, and C. Jorgensen, “Engineered mesenchymal stem cells for cartilage repair,” Regenerative Medicine, vol. 1, no. 4, pp. 529–537, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. S. M. Kunisaki, D. A. Freedman, and D. O. Fauza, “Fetal tracheal reconstruction with cartilaginous grafts engineered from mesenchymal amniocytes,” Journal of Pediatric Surgery, vol. 41, no. 4, pp. 675–682, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. P. De Coppi, A. Callegari, A. Chiavegato et al., “Amniotic fluid and bone marrow derived mesenchymal stem cells can be converted to smooth muscle cells in the cryo-injured rat bladder and prevent compensatory hypertrophy of surviving smooth muscle cells,” The Journal of Urology, vol. 177, no. 1, pp. 369–376, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Parekkadan and J. M. Milwid, “Mesenchymal stem cells as therapeutics,” Annual Review of Biomedical Engineering, vol. 12, no. 1, pp. 87–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Weidner, J. P. Semple, W. R. Welch, and J. Folkman, “Tumor angiogenesis and metastasis—correlation in invasive breast carcinoma,” New England Journal of Medicine, vol. 324, no. 1, pp. 1–8, 1991. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Kim, Y. Lee, H. Kim et al., “Human amniotic fluid-derived stem cells have characteristics of multipotent stem cells,” Cell Proliferation, vol. 40, no. 1, pp. 75–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. P. De Coppi, G. Bartsch, M. M. Siddiqui et al., “Isolation of amniotic stem cell lines with potential for therapy,” Nature Biotechnology, vol. 25, no. 1, pp. 100–106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. C. Mardegan, M. C. Ramos, S. J. Adad, M. A. Michelin, D. Shimba, and E. F. Murta, “Immunological evaluation of vaginal secretion in patients with high-grade cervical intraepethelial neoplasia treated with intralesional interferon α-2b,” European Journal of Gynaecological Oncology, vol. 32, no. 3, pp. 297–302, 2011. View at Google Scholar
  30. A. Y. Khakoo, S. Pati, S. A. Anderson et al., “Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi’s sarcoma,” Journal of Experimental Medicine, vol. 203, no. 5, pp. 1235–1247, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Gutova, J. Najbauer, R. T. Frank et al., “Urokinase plasminogen activator and urokinase plasminogen activator receptor mediate human stem cell tropism to malignant solid tumors,” Stem Cells, vol. 26, no. 6, pp. 1406–1413, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. I. Türkçüoğlu, S. Tezcan, G. Kaygusuz et al., “The role of p53, bcl-2 and ki-67 in premalignant cervical lesions and cervical cancer,” European journal of Gynaecological Oncology, vol. 28, no. 4, pp. 290–293, 2007. View at Google Scholar
  33. F. Gimenes, R. P. Souza, A. L. P. de Abreu, M. W. Pereira, M. E. L. Consolaro, and V. R. S. da Silva, “Simultaneous detection of human papillomavirus integration and c-MYC gene amplification in cervical lesions: an emerging marker for the risk to progression,” Archives of Gynecology and Obstetrics, vol. 293, no. 4, pp. 857–863, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. W.-H. Zhao, M. Hao, X.-t. Cheng et al., “c-myc gene copy number variation in cervical exfoliated cells detected on fluorescence in situ hybridization for cervical cancer screening,” Gynecologic and Obstetric Investigation, vol. 81, no. 5, pp. 416–423, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Ren, S. Kumar, D. Chanda, J. Chen, J. D. Mountz, and S. Ponnazhagan, “Therapeutic potential of mesenchymal stem cells producing interferon-α in a mouse melanoma lung metastasis model,” Stem Cells, vol. 26, no. 9, pp. 2332–2338, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Otsu, S. Das, S. D. Houser, S. K. Quadri, S. Bhattacharya, and J. Bhattacharya, “Concentration-dependent inhibition of angiogenesis by mesenchymal stem cells,” Blood, vol. 113, no. 18, pp. 4197–4205, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Lis, C. Touboul, C. M. Raynaud et al., “Mesenchymal cell interaction with ovarian cancer cells triggers pro-metastatic properties,” PLoS One, vol. 7, no. 5, article e38340, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. R. Lis, C. Touboul, P. Mirshahi et al., “Tumor associated mesenchymal stem cells protects ovarian cancer cells from hyperthermia through CXCL12,” International Journal of Cancer, vol. 128, no. 3, pp. 715–725, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. S. B. Coffelt, F. C. Marini, K. Watson et al., “The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 10, pp. 3806–3811, 2009. View at Publisher · View at Google Scholar · View at Scopus