Human Placenta-Derived Mesenchymal Stem Cells Reduce Mortality and Hematoma Size in a Rat Intracerebral Hemorrhage Model in an Acute Phase

Figure 4

Human placenta-derived mesenchymal stem cells (PD-MSCs) enhanced the expression of tight junction proteins at 24 hours after ICH induction but did not affect the expression of coagulation factor VII mRNA. (a) Results of Western blot of ZO-1 and occludin at 6 and 24 hours after ICH induction. Bar graphs indicate the level of ZO-1 (b) and occludin (c) expression measured by the densitometric analysis of the bands. β-Actin was used as a loading control. Data are mean + SEM; from each group, . (d) Real-time PCR analysis of coagulation factor VII (F7) at 6 and 24 hours after ICH induction, and that at 24 hours after sham operation. The level of F7 mRNA was normalized to that of GAPDH mRNA. Data are mean + SEM; from each group, .

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