Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells

Figure 3

OCT4, SOX2, NANOG, and KLF4 expression. Selected markers of self-renewal and differentiation potential (OCT4, SOX2, NANOG, and KLF4) were evaluated by RT-PCR (a) and cytofluorometry (b). For PCR analysis, the expression levels measured in LPCs are considered as X-fold with respect to MPCs (considered as 1). Data are mean ± SD of analyses performed in 12 different MPC and LPC cultures, upon three independent experiments in triplicates. LPCs versus MPCs. For cytofluorometric analysis, representative FACScan analyses of cell-surface antigen expression, as indicated. Black histograms refer to the MPCs and red histograms refer to LPCs.

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