Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice

Figure 1

Experimental protocol and time schedule. pMCAo: permanent middle cerebral artery occlusion; IV: intravenous; PBS: phosphate-buffered saline; PB-MNC: peripheral blood mononuclear cells; PB-MNC+: peripheral blood mononuclear cells stimulated by ephrin-B2; BBB: blood-brain barrier; SVZ: subventricular zone. There were 3 groups for each endpoint (number of mice/group). Infarct volume was not assessed at D14 because the infarct was barely detectable. Peri-infarct cell proliferation and angiogenesis evaluated on Ki67+/CD31+ double-positive cell density were not performed at D14, because of the scarce number of Ki67+ cells in the peri-infarct area at D14.