Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway

Figure 6

The migration of BrdU-labeled BMSCs in vivo. (a) To observe the migration of BMSCs in vivo, BMSCs were labeled with BrdU. All cells stained with DAPI were shown in blue, while BrdU-positive cells were labeled with red fluorescence. (b) The labeling efficiency of BrdU was 95 ± 2.1%. (c) BrdU⁺ cells were detected by an immunofluorescence assay at 4 weeks after surgery. The number of BMSCs treated with ICA in the repairing tissue is much greater than that in the group injected with control BMSCs. (d) Statistical data analysis of the positive cell percentage in Figure 6(c). compared with the BMSC control.

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