Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

<div>Effect of AMSC-EVs in rats with CCl<sub>4</sub>-induced liver fibrosis. (a) Hematoxylin and eosin staining. (b) Masson trichrome staining. (c) Expression of <i>α</i>-smooth muscle action (SMA). (d) Expression of CD68. 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330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.24,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,41.204,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,47.444,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> versus CCl<sub>4</sub>. Scale bar, 200 <i>μ</i>m. AMSC: amnion-derived mesenchymal stem cell; EV: extracellular vesicle; CCl<sub>4</sub>: carbon tetrachloride.</div>

Stem Cells International

fig4

Figure 4

Figure 4: Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats 