Research Article

Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs

Figure 2

Statistics of metabolic clustering. (a) Box-and-whisker plots of metabolite signal intensities measured in MR spectra from GSC lines belonging to cluster 1a (blue), 1b (brown), and 2 (pink). Intensities of NAA, GABA, Gln, A, Myo-I, Asp, Glu, GSH, PC, and GPC were quantified in 2D COSY spectra and GalNAc, UDP, Gly, ML, and tCr in 1D spectra. (b) log2(FC) ((FC) fold change) of metabolite signal intensities of cluster 1b with respect to cluster 1a, of cluster 2 with respect to cluster 1a, and of cluster 2 with respect to cluster 1b. Only significant changes are reported with , , and .
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