Research Article
Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs
Figure 6
Analysis of the effects induced by oligomycin treatment. (a) Ratios of fluorescence signal values of treated samples (FL1 and FL2 oligomycin) and those of control ones (FL1 and FL2-C). Trend of ML (b) and PC + GPC (c) signal intensities from 1D spectra of control and oligomycin-treated #61, #74, #1, and #163 line samples. Percentage variation of cell number (d) and lactate signal intensity, measured with respect to cell number [(Lac/N)oli − (Lac/N)con]/(Lac/N)con, after 24 h oligomycin treatment (e) Representative spectra of line #163 after treatment are reported in Figure S3C. (f) Ratio of lactate signal intensity of control (Laccon) and olygomicin-treated samples (Lacoli) as a function of time. (g) Values after 24 hours of treatment are reported for all the analyzed lines.
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