Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs

<div>Analysis of the effects induced by etomoxir treatment. (a) Changes in cell number percentage induced by 7-hour etomoxir treatment in cell lines #1 and #163. (b) Effects of etomoxir treatment on ML and Glc signals in 1D MR spectra of lines #1 and #163. Trend of ML (c) and PC + GPC (d) signal intensities from 1D spectra of control and etomoxir-treated #1 and #163 line samples. (e) Percentage variation of lactate signal intensity measured compared to cell number ([(Lac/N)eto (Lac/N)con]/(Lac/N)con) 7 h after etomoxir treatment.</div>

Stem Cells International

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Figure 7

Figure 7: Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs 

Figure 7 | Metabolic Heterogeneity Evidenced by MRS among Patient-Derived Glioblastoma Multiforme Stem-Like Cells Accounts for Cell Clustering and Different Responses to Drugs 