TY - JOUR A2 - Yu, Bo AU - Guo, Yu-chen AU - Zhang, Shi-wen AU - Yuan, Quan PY - 2018 DA - 2018/07/08 TI - Deubiquitinating Enzymes and Bone Remodeling SP - 3712083 VL - 2018 AB - Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in several cell functions. Importantly, a number of deubiquitinases mediate bone remodeling through regulating differentiation and/or function of osteoblast and osteoclasts. In this review, we review the functions and mechanisms of deubiquitinases in mediating bone remodeling. SN - 1687-966X UR - https://doi.org/10.1155/2018/3712083 DO - 10.1155/2018/3712083 JF - Stem Cells International PB - Hindawi KW - ER -