Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-α

Figure 1

UC-MSCs alleviated the severity of arthritis and histological scores, comparable to TNF-α inhibitor treatment. (a) Arthritis scores in the collagen-induced arthritis (CIA) groups with different treatments ( in each group). CIA mice were treated with PBS (control), antitumor necrosis factor- (TNF-) α, zoledronic acid (ZA), and umbilical cord mesenchymal stem cells (UC-MSCs). (b) The evaluation of histological scores of H&E-stained sections in different groups ( in each group). (c) H&E-stained sagittal sections of knee joints from CIA mice (photographed at ×100). Arrow indicates fibrinoid necrosis. ; ; .

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