Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools

Figure 4

Functional tests. According to Figure 1, functional tests evaluating muscle efficiency in the upper (FAT) and lower limbs (2MWT, TUG, and 5STS) and trunk (TCT) were performed in several time points before, in the course of, and after ADRC therapy. The stability or decrease in these functions was compared with the trajectory of the ALSFRS scale. Impairment in all functional tests was observed faster than decrease in ALSFRS. Although 5STS and TUG showed good correlation with other functional parameters, their longitudinal use was limited in patients who were no longer able to stand up without the help of their arms/hands (on average 6–9 months after the first transplantation; P3 and P4).