Clinical Study

Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools

Table 1

Inclusion and exclusion criteria for the intraspinal and intrathecal ADRC transplantation.

Inclusion criteriaExclusion criteria

(i) Clinically definite or probable ALS(i) PEG or indications for PEG insertion
(ii) Age 18–65 years(ii) Respiratory insufficiency, NIPPV, IV, or indications
(iii) (iii) SOD1 and C9orf72 mutation
(iv) (iv) Concomitant disorders with contraindications for neurosurgery
(v) Stable dose of riluzole for the past 30 days(v) Pregnancy or lactation
(vi) Disease duration 6–24 months(vi) Unable to provide informed consent
(vii) Pretreatment observation period of >3 months (neurological and physiotherapist assessment, ALSFRS R, and MUNIX)
(viii) In females with childbearing potential at least two efficient contraceptive methods
(ix) Able to provide informed consent