Intraspinal Transplantation of the Adipose Tissue-Derived Regenerative Cells in Amyotrophic Lateral Sclerosis in Accordance with the Current Experts’ Recommendations: Choosing Optimal Monitoring Tools

Table 2

Timetable of the adipose-derived regenerative cell (ADRC) isolation and transplantation study.

Action visit	V1 screening	V2	V3	V4	V5	V6	V7
Week	−24	−12	0	12	24	36	48
Permitted delta in weeks to V1		+2		+2	+2	+/−2	+/−2
Interventions
Intraspinal transplantation			X
Intrathecal transplantation				X	X
Screening assessment
Patient information, informed consent	X		X	X	X
Inclusion/exclusion criteria	X
Medical history	X		X	X	X	X	X
Diagnosis according to EEC	X		X	X	X	X	X
Physical and neurological examination	X	X	X	X	X	X	X
EMG	X
MUNIX	X	X	X	X	X	X	X
Spinal MRI C with contrast			X
Spinal MRI Th with contrast			X	X	X		X
Spinal MRI S with contrast			X	X	X		X
Spinal MRI Th			X	X	X
Spinal MRI LS			X	X	X
Spirometry	X	X	X	X	X	X	X
Chest X-ray			X
Laboratory studies	X		X	X	X
Muscle strength assessment
MRC	X	X	X	X	X	X	X
HHD	X	X	X	X	X	X	X
Functional assessment
ALSFRS R	X	X	X	X	X	X	X
2MWT (with concomitant BS)	X	X	X	X	X	X	X
5STS	X	X	X	X	X	X	X
TUG	X	X	X	X	X	X	X
TCT	X	X	X	X	X	X	X
FAT	X	X	X	X	X	X	X
Other examinations
FSS	X	X	X	X	X	X	X
MAS	X	X	X	X	X	X	X
Psychological assessment
ADI-12	X		X		X		X
ACSA	X		X		X		X

MUNIX: motor unit number index (MUNIX). Examination performer 48 h after the ARDC transplantation. MRC: Manual Muscle Test Medical Research Council; HHD: handheld dynamometer (HHD); ALSFRS R: amyotrophic lateral sclerosis functional rating scale-revised; 2MWT: two-minute walk test; BS: Borg scale; 5STS: Five Times Sit to Stand test; TUG: Timed Up and Go; FAT: Frenchay Arm Test; TCT: Trunk Control Test; MAS: Modified Ashworth Scale; FSS: Fatigue Severity Scale; ADI-12: ALS Depression Inventory; ACSA: Anamnestic Comparative Self-Assessment.