Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma

Figure 3

PET/CT tracking of hD2R_hMPCs in a TA crush injury model. (a) Nude mice were subjected to a TA crush injury, followed by injection of cell collagen suspension. (b) Feasible tracking of hD2R_hMPCs with [¹⁸F]Fallypride in a virus dose-dependent manner (25% versus 50% hD2R-positive cells). No tracer uptake in the TA crush only (cr). (c) [¹¹C]Raclopride accumulation in hD2R_hPGC-1α_hMPCs at early time points, but not at midterm and late. (d) Enhanced accumulation of [¹¹C]Raclopride at GFP_hMPC injection site, compared to hD2R_hPGC-1α_hMPCs. SUV: standardized uptake value (the same scale used for all), cr: crush only.

(a)

(b)

(c)

(d)