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Stem Cells International
Volume 2018, Article ID 4695275, 11 pages
https://doi.org/10.1155/2018/4695275
Research Article

Influence of Genetically Modified Human Umbilical Cord Blood Mononuclear Cells on the Expression of Schwann Cell Molecular Determinants in Spinal Cord Injury

1Kazan Federal University, Kazan, Russia
2Kazan State Medical University, Kazan, Russia

Correspondence should be addressed to Y. O. Mukhamedshina; ur.liam@n-z-k.anay

Received 8 August 2017; Revised 24 November 2017; Accepted 12 December 2017; Published 18 February 2018

Academic Editor: Daniel Pelaez

Copyright © 2018 L. R. Galieva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Spinal cord injury (SCI) unavoidably results in death of not only neurons but also glial cells. In particular, the death of oligodendrocytes leads to impaired nerve impulse conduction in intact axons. However, after SCI, the Schwann cells (SCs) are capable of migrating towards an area of injury and participating in the formation of functional myelin. In addition to SCI, cell-based therapy can influence the migration of SCs and the expression of their molecular determinants. In a number of cases, it can be explained by the ability of implanted cells to secrete neurotrophic factors (NTFs). Genetically modified stem and progenitor cells overexpressing NTFs have recently attracted special attention of researchers and are most promising for the purposes of regenerative medicine. Therefore, we have studied the effect of genetically modified human umbilical cord blood mononuclear cells on the expression of SC molecular determinants in SCI.