Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2018, Article ID 4695275, 11 pages
https://doi.org/10.1155/2018/4695275
Research Article

Influence of Genetically Modified Human Umbilical Cord Blood Mononuclear Cells on the Expression of Schwann Cell Molecular Determinants in Spinal Cord Injury

1Kazan Federal University, Kazan, Russia
2Kazan State Medical University, Kazan, Russia

Correspondence should be addressed to Y. O. Mukhamedshina; ur.liam@n-z-k.anay

Received 8 August 2017; Revised 24 November 2017; Accepted 12 December 2017; Published 18 February 2018

Academic Editor: Daniel Pelaez

Copyright © 2018 L. R. Galieva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. X. Zhang, F. Huang, M. Gates, and E. G. Holmberg, “Role of endogenous Schwann cells in tissue repair after spinal cord injury,” Neural Regeneration Research, vol. 8, no. 2, pp. 177–185, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Bachelin, F. Lachapelle, and C. Girard, “Efficient myelin repair in the macaque spinal cord by autologous grafts of Schwann cells,” Brain, vol. 128, no. 3, pp. 540–549, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. J. F. Talbott, Q. Cao, G. U. Enzmann et al., “Schwann cell-like differentiation by adult oligodendrocyte precursor cells following engraftment into the demyelinated spinal cord is BMP-dependent,” Glia, vol. 54, no. 3, pp. 147–159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Zawadzka, L. E. Rivers, S. P. Fancy et al., “CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination,” Cell Stem Cell, vol. 6, no. 6, pp. 578–590, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Bartus, J. Galino, and N. D. James, “Neuregulin-1 controls an endogenous repair mechanism after spinal cord injury,” Brain, vol. 139, no. 5, pp. 1394–1416, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. Q. Cao, X. M. Xu, W. H. Devries et al., “Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells,” The Journal of Neuroscience, vol. 25, no. 30, pp. 6947–6957, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Iwase, C. G. Jung, H. Bae, M. Zhang, and B. Soliven, “Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells,” Journal of Neurochemistry, vol. 94, no. 6, pp. 1488–1499, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Zhang, Z. Ma, G. M. Smith et al., “GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons,” Glia, vol. 57, no. 11, pp. 1178–1191, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Storkebaum, D. Lambrechts, and P. Carmeliet, “VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection,” Bioessays, vol. 26, no. 9, pp. 943–954, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. C. T. Chen, N. H. Foo, W. S. Liu, and S. H. Chen, “Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms,” Pediatrics and Neonatology, vol. 49, no. 3, pp. 77–83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. V. R. Dasari, K. K. Veeravalli, A. J. Tsung et al., “Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury,” Journal of Neurotrauma, vol. 26, no. 11, pp. 2057–2069, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. O. Mukhamedshina, E. E. Garanina, G. A. Masgutova et al., “Assessment of glial scar, tissue sparing, behavioral recovery and axonal regeneration following acute transplantation of genetically modified human umbilical cord blood cells in a rat model of spinal cord contusion,” PLoS One, vol. 11, no. 3, article e0151745, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Pomyje, J. Zivný, L. Sefc, M. Plasilová, R. Pytlík, and E. Necas, “Expression of genes regulating angiogenesis in human circulating hematopoietic cord blood CD34+/CD133+ cells,” European Journal of Haematology, vol. 70, no. 3, pp. 143–150, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Bracci-Laudiero, D. Celestino, G. Starace et al., “CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA,” Journal of Neuroimmunology, vol. 136, no. 1-2, pp. 130–139, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. O. Mukhamedshina, G. F. Shaymardanova, Е. Е. Garanina et al., “Adenoviral vector carrying glial cell-derived neurotrophic factor for direct gene therapy in comparison with human umbilical cord blood cell-mediated therapy of spinal cord injury in rat,” Spinal Cord, vol. 54, no. 5, pp. 347–359, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. O. Mukhamedshina, Z. E. Gilazieva, S. S. Arkhipova et al., “Electrophysiological, morphological, and ultrastructural features of the injured spinal cord tissue after transplantation of human umbilical cord blood mononuclear cells genetically modified with the VEGF and GDNF genes,” Neural Plasticity, vol. 2017, Article ID 9857918, 12 pages, 2017. View at Google Scholar
  17. Y. Sato, M. Kimura, C. Yasuda et al., “Evidence for the presence of major peripheral myelin glycoprotein P0 in mammalian spinal cord and a change of its glycosylation state during aging,” Glycobiology, vol. 9, no. 7, pp. 655–660, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. K. R. Jessen and R. Mirsky, “The origin and development of glial cells in peripheral nerves,” Nature Reviews. Neuroscience, vol. 6, no. 9, pp. 671–682, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Escurat, K. Djabali, M. Gumpel, F. Gros, and M. M. Portier, “Differential expression of two neuronal intermediate-filament proteins, peripherin and the low-molecular-mass neurofilament protein (NF-L), during the development of the rat,” The Journal of Neuroscience, vol. 10, no. 3, pp. 764–784, 1990. View at Google Scholar
  20. W. T. Clarke, B. Edwards, K. J. A. McCullagh et al., “Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons,” Journal of Cell Science, vol. 123, no. 15, pp. 2543–2552, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Y. Song, J. H. Zhong, X. Wang, and X. F. Zhou, “Suppression of p75NTR does not promote regeneration of injured spinal cord in mice,” Journal of Neuroscience, vol. 24, no. 2, pp. 542–546, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. S. De and J. E. Turman Jr, “Krox-20 gene expression: influencing hindbrain-craniofacial developmental interactions,” Archives of Histology and Cytology, vol. 68, no. 4, pp. 227–234, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Hagg and M. Oudega, “Degenerative and spontaneous regenerative processes after spinal cord injury,” Journal of Neurotrauma, vol. 23, no. 3-4, pp. 263–280, 2006. View at Publisher · View at Google Scholar
  24. A. A. Lavdas, F. Papastefanaki, D. Thomaidou, and R. Matsas, “Schwann cell transplantation for CNS repair,” Current Medicinal Chemistry, vol. 15, no. 2, pp. 151–160, 2008. View at Google Scholar
  25. V. Zujovic, C. Bachelin, and A. Baron-Van Evercooren, “Remyelination of the central nervous system: a valuable contribution from the periphery,” The Neuroscientist, vol. 13, no. 4, pp. 383–391, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Jasmin, G. Janni, T. M. Moallem, D. A. Lappi, and P. T. Ohara, “Schwann cells are removed from the spinal cord after effecting recovery from paraplegia,” The Journal of Neuroscience, vol. 20, no. 24, pp. 9215–9223, 2000. View at Google Scholar
  27. M. Dezawa and E. Adachi-Usami, “Role of Schwann cells in retinal ganglion cell axon regeneration,” Progress in Retinal and Eye Research, vol. 19, no. 2, pp. 171–204, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. J. K. Kim, H. J. Lee, and H. T. Park, “Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases: pro-demyelinating and axon-preservative functions,” Neural Regeneration Research, vol. 9, no. 22, pp. 1952–1954, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. H. J. Lee, Y. K. Shin, and H. T. Park, “Mitogen activated protein kinase family proteins and c-jun signaling in injury-induced Schwann cell plasticity,” Experimental neurobiology, vol. 23, no. 2, pp. 130–137, 2014. View at Publisher · View at Google Scholar
  30. S. X. Zhang, F. Huang, M. Gates, J. White, and E. G. Holmberg, “Histological repair of damaged spinal cord tissue from chronic contusion injury of rat: a LM observation,” Histology and Histopathology, vol. 26, no. 1, pp. 45–58, 2011. View at Publisher · View at Google Scholar
  31. S. Britsch, D. E. Goerich, D. Riethmacher et al., “The transcription factor Sox10 is a key regulator of peripheral glial development,” Genes & Development, vol. 15, no. 1, pp. 66–78, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Qin, L. Wang, L. Zheng et al., “Concentrated growth factor promotes Schwann cell migration partly through the integrin β1-mediated activation of the focal adhesion kinase pathway,” International Journal of Molecular Medicine, vol. 37, no. 5, pp. 1363–1370, 2016. View at Publisher · View at Google Scholar · View at Scopus
  33. E. S. Anton, G. Weskamp, L. F. Reichardt, and W. D. Matthew, “Nerve growth factor and its low-affinity receptor promote Schwann cell migration,” Proceedings of the National Academy of Sciences, vol. 91, no. 7, pp. 2795–2799, 1994. View at Publisher · View at Google Scholar
  34. J. Yamauchi, J. R. Chan, and E. M. Shooter, “Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on rho GTPases,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 23, pp. 8774–8779, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Blesch and M. H. Tuszynski, “Transient growth factor delivery sustains regenerated axons after spinal cord injury,” The Journal of Neuroscience, vol. 27, no. 39, pp. 10535–10545, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Sondell, G. Lundborg, and M. Kanje, “Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system,” The Journal of Neuroscience, vol. 19, no. 14, pp. 5731–5740, 1999. View at Google Scholar
  37. Y. O. Mukhamedshina, G. F. Shaymardanova, A. R. Muhitov et al., “Survival and differentiation of endogenous schwann cells migrating into spinal cord under the influence of neurotrophic factors,” Gene and Cells, vol. 7, no. 3, pp. 125–129, 2012. View at Google Scholar
  38. G. Lemke and R. Axel, “Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin,” Cell, vol. 40, no. 3, pp. 501–508, 1985. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Antonellis, M. Y. Dennis, G. Burzynski et al., “A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo,” PloS One, vol. 5, no. 12, article e14346, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. C. S. Gillespie, B. D. Trapp, D. R. Colman, and P. J. Brophy, “Distribution of myelin basic protein and P2 mRNAs in rabbit spinal cord oligodendrocytes,” Journal of Neurochemistry, vol. 54, no. 5, pp. 1556–1561, 1990. View at Publisher · View at Google Scholar · View at Scopus
  41. M. M. Watila and S. A. Balarabe, “Molecular and clinical features of inherited neuropathies due to PMP22 duplication,” Journal of the Neurological Sciences, vol. 355, no. 1-2, pp. 18–24, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Li, B. Parker, C. Martyn, C. Natarajan, and J. Guo, “The PMP22 gene and its related diseases,” Molecular Neurobiology, vol. 47, no. 2, pp. 673–698, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Moghieb, H. M. Bramlett, J. H. Das et al., “Differential neuroproteomic and systems biology analysis of spinal cord injury,” Molecular & Cellular Proteomics, vol. 15, no. 7, pp. 2379–2395, 2016. View at Publisher · View at Google Scholar · View at Scopus