Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes

Figure 5

Detailed representation of expression changes of selected miRNAs in HLCs at days 20 and 24 of differentiation (d20 and d24, resp.) in comparison to hepatocytes: (a) hepatic-specific miRNAs (miR-122-5p, miR-27b-3p, miR-23b-3p, and miR-148-3p); miRNAs upregulated at day 24 of hepatic differentiation; (b) fetal liver-specific miRNAs (miR-23a-3p, miR-30a-5p, miR-483-3p, and miR-92b-3p); (c) miRNAs related to epithelial phenotype of HLCs (miR-200c-3p, miR-204, miR-429, and miR-199a-3p); (d) miRNAs connected to PI3K signaling (miR-21-5p, miR-21-3p, miR-214-3p, and miR-216a-5p).

(a)

(b)

(c)

(d)