Stem Cells International / 2018 / Article / Tab 1

Research Article

Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes

Table 1

Gene ontology categories of differentially expressed miRNA targets (pathway union).

ComparisonKEGG pathway value#genes#miRNAs

Upregulated miRNAs in HLC d24 compared to HLC d20Fatty acid biosynthesis012
ECM-receptor interaction0104
Fatty acid metabolism5.984709e – 1022
Proteoglycans in cancer2.928118e − 09313
Hippo signaling pathway0.0001180971133
Steroid biosynthesis0.00404809222
Adherens junction0.01782237112
Base excision repair0.0270815342

Upregulated miRNAs in HLC d20 compared to HLC d24Lysine degradation1.389225e − 0892
Chronic myeloid leukemia0.0001602018132
Proteoglycans in cancer0.0002270705121
Wnt signaling pathway0.0006146658121
FoxO signaling pathway0.003220974182
Cell cycle0.00329553591
Pathways in cancer0.004235095171
Progesterone-mediated oocyte maturation0.0336434381
Oocyte meiosis0.0339808751
Signaling pathways regulating pluripotency of stem cells0.0589956491

Upregulated miRNAs in HLC d20 compared to hepatocytesFatty acid biosynthesis044
ECM-receptor interaction02910
Lysine degradation02617
Proteoglycans in cancer011518
MicroRNAs in cancer2.065015e − 14553
Adherens junction1.92849e − 105614
Fatty acid metabolism2.435736e − 07125
Hippo signaling pathway2.854731e − 077615
Prion diseases3.567319e − 0721
Viral carcinogenesis4.563306e − 079010
Pathways in cancer7.078609e − 0515511
Cell cycle0.0002485214629
p53 signaling pathway0.027620944210
Transcriptional misregulation in cancer0.02815897708

Upregulated miRNAs in hepatocytes compared to HLC d20Fatty acid biosynthesis047
ECM-receptor interaction03915
Lysine degradation02617
Cell cycle09217
Viral carcinogenesis012919
Hippo signaling pathway09223
Proteoglycans in cancer014023
Pathways in cancer1.110223e − 1623520
Adherens junction8.881784e – 165920
Hepatitis B3.774758e − 158313
Chronic myeloid leukemia3.940404e − 125418
Colorectal cancer3.432521e − 114317
Glioma9.944934e – 114315
Fatty acid metabolism1.771966e – 06148
p53 signaling pathway2.456315e – 064716
Small cell lung cancer8.452771e – 065714
Oocyte meiosis1.56543e − 056512
Thyroid hormone signaling pathway2.996244e – 056411
Steroid biosynthesis8.629469e – 05712
Prostate cancer0.00049101156513
PI3K-Akt signaling pathway0.00150645111810
Focal adhesion0.001709285819
TGF-beta signaling pathway0.004683835489

Upregulated miRNAs in HLC d24 compared to hepatocytesPrion diseases022
Fatty acid biosynthesis046
Fatty acid metabolism0149
Proteoglycans in cancer010715
ECM-receptor interaction03418
Adherens junction2.136489e – 105216
Viral carcinogenesis2.367215e – 078411
Hippo signaling pathway8.686167e – 057614
Pathways in cancer0.0010982151358
Lysine degradation0.0013379382410
Transcriptional misregulation in cancer0.003591186537
p53 signaling pathway0.045916013911

Upregulated miRNA hepatocytes compared to HLC d24Fatty acid biosynthesis047
Hepatitis B09115
ECM-receptor interaction04116
Lysine degradation02718
Cell cycle09318
Viral carcinogenesis013218
Pathways in cancer024721
Hippo signaling pathway09122
Proteoglycans in cancer014323
Adherens junction5.662137e – 155819
Chronic myeloid leukemia1.465494e – 145819
Glioma8.104628e – 144616
Colorectal cancer8.277157e – 124518
p53 signaling pathway2.698853e – 084717
Oocyte meiosis1.888721e – 076713
Small cell lung cancer5.78931e − 076115
Thyroid hormone signaling pathway1.055741e – 056411
Prion diseases2.777397e – 0562
Steroid biosynthesis4.649816e – 051011
TGF-beta signaling pathway6.111763e – 055211
Prostate cancer0.00011055536613
Fatty acid metabolism0.0001381028137
PI3K-Akt signaling pathway0.000199128613811
FoxO signaling pathway0.0011078388415
Focal adhesion0.001779401909
Bladder cancer0.0028330662712
Melanoma0.011821364110
Protein processing in endoplasmic reticulum0.0143695410512
Endocytosis0.014459439712

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