Human Umbilical Cord MSC-Derived Exosomes Suppress the Development of CCl₄-Induced Liver Injury through Antioxidant Effect

Figure 5

hucMSC-Ex exerted a more effective antioxidant than DDB in CCl₄-induced liver injury. (a, b) Immunohistochemistry staining of 8-OHdG in mouse livers after treatment with DDB (8 mg/kg, 16 mg/kg, and 32 mg/kg) or hucMSC-Ex (6 × 10¹⁰ particles/kg, 1.2 × 10¹¹ particles/kg, and 2.4 × 10¹¹ particles/kg) (; , , and ). (c, d) Immunohistochemistry staining of activated caspase 3 in mouse livers after treatment with DDB (8 mg/kg, 16 mg/kg, and 32 mg/kg) or hucMSC-Ex (6 × 10¹⁰ particles/kg, 1.2 × 10¹¹ particles/kg, and 2.4 × 10¹¹ particles/kg) (; ). Compared with the PBS group, hucMSC-Ex (2.4 × 10¹¹ particles/kg) exerted a more distinct inhibition effect in the expression of 8-OHdG and activated caspase 3. Original magnification 200x.

(a)

(b)

(c)

(d)