Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells

Figure 4

GBP1 is required for upregulation of MMP2 by IFN-γ treatment in PDLSCs. RT-qPCR analysis of matrix metalloproteinase gene expression after 48 hours of IFN-γ treatment in PDLSCs and control cells (a–d). MMP2 expression was upregulated by IFN-γ treatment in a dose-dependent manner (b and e). The IFN-γ-induced upregulation of MMP2 was inhibited by depletion of GBP1 as determined by RT-qPCR analysis and Western blot (f and g). ; .

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