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Stem Cells International
Volume 2018, Article ID 6392986, 14 pages
https://doi.org/10.1155/2018/6392986
Review Article

Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease

1Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea
2Department of Dental Hygiene, Daejeon Institute of Science and Technology, Daejeon, Republic of Korea

Correspondence should be addressed to Young-Seok Park; rk.ca.uns@7oyaoya

Received 19 November 2017; Accepted 15 January 2018; Published 1 March 2018

Academic Editor: Shimon Slavin

Copyright © 2018 Kyeong-Ah Kwak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.