D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion

Figure 4

D-mannose inhibited IL-6 secretion of hPDLSCs to induce more T cell differentiation into Tregs in vivo. (a, b) IL-6 reduction could increase the number of FoxP3 and CD25 double positive cells in T + G-hPDLSC mixed cell-injected mice. (c, d) In vivo, compared with the T + G-hPDLSCs group, there was less Th1 cell in T + M-hPDLSC mixed cell-injected mice. (c, e) In vivo, IL-6 reduction could decrease the number of Th17 cell in T + G-hPDLSC mixed cell-injected mice. Student’s t-test and one way ANOVA were used to analyze statistical significance. All error bars represent s.d. (). , , and .

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