Mesenchymal Stem Cells Enhance Liver Regeneration via Improving Lipid Accumulation and Hippo Signaling

Figure 5

Effects of MSCs on cytokines and the STAT3 and Hippo pathways after PHx. (a) RT-qPCR analysis for the mRNA levels of IL-6, TNF-α, and IL-1β in the liver in each group at 24 h and 48 h after PHx (). (b) ELISA analysis for the serum levels of IL-6 in each group at 24 h and 48 h after PHx (). (c) Western blotting of the markers of STAT3 signaling (p-STAT3, STAT3, and SOCS3), antiapoptosis (Bcl2 and Bcl-xl), and YAP in the liver in each group at 24 h and 48 h after PHx. (d) RT-qPCR analysis for the mRNA levels of YAP targeted genes (Areg, Birc5, Ctgf, Cyr61, and Foxm1) (). Values represent mean ± SD. ; .

(a)

(b)

(c)

(d)