Stem Cells International / 2018 / Article / Tab 1

Review Article

Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering

Table 1

Potential markers for MSC identification and enrichment.

Selection type (and comments)CD No.NameAcronymReference

NegativeCD11bIntegrin subunit alpha MITGAM[5]
NegativeCD14CD14 moleculeCD14[5]
NegativeCD19CD19 moleculeCD19[5]
Negative (not in all MSC populations)CD34CD34 moleculeCD34[5]
NegativeCD45Protein tyrosine phosphatase, receptor type CPTPRC[5]
NegativeCD79aCD79a moleculeCD79A[5]
Negative (unless stimulated with IFN-γ)Human leukocyte antigen, antigen D RelatedHLA-DR[5]
PositiveCD9CD9 moleculeCD9[172]
PositiveCD10Membrane metalloendopeptidaseMME[173]
PositiveCD13Alanyl aminopeptidase, membraneANPEP[174]
PositiveCD29Integrin subunit beta 1ITGB1[175]
PositiveCD44CD44 molecule (Indian blood group)CD44[176]
PositiveCD49fIntegrin subunit alpha 6ITGA6[177]
PositiveCD54Intercellular adhesion molecule 1ICAM1[178]
PositiveCD71Transferrin receptorTFRC[179]
PositiveCD735-nucleotidase ectoNT5E[5]
PositiveCD90Thy-1 cell surface antigenTHY1[5]
PositiveCD106Vascular cell adhesion molecule 1VCAM1[11]
PositiveCD146Melanoma cell adhesion moleculeMCAM[10]
PositiveCD166Activated leukocyte cell adhesion moleculeALCAM[180]
PositiveCD200CD200 moleculeCD200[181]
PositiveCD271Nerve growth factor receptorNGFR[12]
PositiveCD349Frizzled class receptor 9FZD9[173]
PositiveCD362Syndecan 2SDC2[182]
Positive (a disialoganglioside, nonpeptide)Ganglioside GD2G2[183]
Positive (also known as nucleostemin)G protein nucleolar 3GNL3[184]
Positive (target of anti-STRO1 antibodies)Heat shock protein family A (Hsp70) member 8HSPA8[185]
PositiveHeat shock protein 90 beta family member 1HSP90B1[186]
Positive (a glycosphingolipid, nonpeptide)Stage-specific embryonic antigen-4SSEA-4[187]
PositiveSushi domain containing 2SUSD2[188]
PositiveAlkaline phosphatase, liver/bone/kidneyALPL[13]

Bolded text indicates markers recommended by the International Society for Cellular Therapy (ISCT) for minimally defining human multipotent mesenchymal stromal cells by positive and negative selection.

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