Stem Cells International / 2018 / Article / Tab 1

Review Article

Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering

Table 1

Potential markers for MSC identification and enrichment.

Selection type (and comments)CD No.NameAcronymReference

NegativeCD11bIntegrin subunit alpha MITGAM[5]
NegativeCD14CD14 moleculeCD14[5]
NegativeCD19CD19 moleculeCD19[5]
Negative (not in all MSC populations)CD34CD34 moleculeCD34[5]
NegativeCD45Protein tyrosine phosphatase, receptor type CPTPRC[5]
NegativeCD79aCD79a moleculeCD79A[5]
Negative (unless stimulated with IFN-γ)Human leukocyte antigen, antigen D RelatedHLA-DR[5]
PositiveCD9CD9 moleculeCD9[172]
PositiveCD10Membrane metalloendopeptidaseMME[173]
PositiveCD13Alanyl aminopeptidase, membraneANPEP[174]
PositiveCD29Integrin subunit beta 1ITGB1[175]
PositiveCD44CD44 molecule (Indian blood group)CD44[176]
PositiveCD49fIntegrin subunit alpha 6ITGA6[177]
PositiveCD54Intercellular adhesion molecule 1ICAM1[178]
PositiveCD71Transferrin receptorTFRC[179]
PositiveCD735-nucleotidase ectoNT5E[5]
PositiveCD90Thy-1 cell surface antigenTHY1[5]
PositiveCD106Vascular cell adhesion molecule 1VCAM1[11]
PositiveCD146Melanoma cell adhesion moleculeMCAM[10]
PositiveCD166Activated leukocyte cell adhesion moleculeALCAM[180]
PositiveCD200CD200 moleculeCD200[181]
PositiveCD271Nerve growth factor receptorNGFR[12]
PositiveCD349Frizzled class receptor 9FZD9[173]
PositiveCD362Syndecan 2SDC2[182]
Positive (a disialoganglioside, nonpeptide)Ganglioside GD2G2[183]
Positive (also known as nucleostemin)G protein nucleolar 3GNL3[184]
Positive (target of anti-STRO1 antibodies)Heat shock protein family A (Hsp70) member 8HSPA8[185]
PositiveHeat shock protein 90 beta family member 1HSP90B1[186]
Positive (a glycosphingolipid, nonpeptide)Stage-specific embryonic antigen-4SSEA-4[187]
PositiveSushi domain containing 2SUSD2[188]
PositiveAlkaline phosphatase, liver/bone/kidneyALPL[13]

Bolded text indicates markers recommended by the International Society for Cellular Therapy (ISCT) for minimally defining human multipotent mesenchymal stromal cells by positive and negative selection.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.