Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine

Table 7

Veterinary clinical studies with MSCs.

Cell source	Cell type	Pathology	Outcome	Reference
Canine	Autologous BM-MSC	Gastrocnemius tendon injury	Repair of tendon	[165]
Canine	Autologous BM-MSC	Chronic Chagas cardiomyopathy	Improved function	[166]
Canine	Autologous AD-MSC	Chronic anconitis	Repair of anconitis	[95]
Canine	Autologous AD-MSC	Arthritis, patella luxation	Repair of arthritis	[167]
Canine	Autologous AD-MSC	Chronic arthritis of hip joint	Repair of arthritis	[168]
Canine	Autologous AD-MSC	Atopic dermatitis	Repair of dermatitis	[169]
Canine	Allogenic AD-MSC	Lumber herniated intervertebral disc	Repair of nerve	[170]
Canine	Allogenic AD-MSC	Hip dysplasia	Improved function	[9]
Canine	Autologous AD-MSC	Chronic osteoarthritis related to hip dysplasia	Reduced lameness	[171]
Canine	Autologous AD-MSC	Severe osteoarthritis	Reduced lameness	[172]
Canine	Human ESC-MSC	Anal furunculosis	Recovery of fistulas	[173]
Feline	Autologous AD-MSC	Chronic kidney disease	Moderate improvement in GFR	[174]
Feline	Allogenic AD-MSC	Chronic kidney disease	Modest improvement in renal function	[175]
Feline	Allogenic AD-MSC	Chronic kidney disease	No adverse effect	[176]
Feline	Autologous AD-MSC	Chronic gingivostomatitis	Reduction in the severity of clinical disease	[177]
Equine	Allogenic UCB-MSC	Chronic laminitis	Repair of laminitis	[178]
Equine	Autologous BM-MSC	Tendon injury	Repair of tendon	[179]
Equine	Autologous BM-MSC	Superficial digital flexor tendon	Repair of tendon	[180]
Equine	Autologous BM-MSC	Tendinitis, desmitis	Repair of inflammation	[181]
Equine	Autologous AD-MSC	Bone spavin	Improvement in inflammatory reaction and clinical conditions	[182]
Equine	Allogenic AD-MSC	Endometriosis	Positive remodeling of endometrial tissue	[183]
Equine	Allogenic AD-MSC and PRP	Superficial digital flexor tendon	Repair of tendonitis	[184]
Equine	Allogenic AD-MSC and PRP	Tendonitis	Improved function	[185]
Dolphin	Autologous AD/BM-MSC	Skin wound	Repair of skin	[186]

AT-MSC: adipose tissue-derived mesenchymal stem cells; UCB-MSC: umbilical cord blood-derived mesenchymal stem cells; BM-MSC: bone marrow-derived mesenchymal stem cells; ESC-MSC: embryonic stem cell-derived mesenchymal stem cells; GFR: glomerular filtration rate; PRP: platelet-rich plasma.