SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction

Table 1

Similarities and differences between SHP2 signaling in different stem cells.

	SHP2-ERK signaling	SHP2-STAT signaling	SHP2-P38 signaling	SHP2-C-jun signaling	SHP2-AKT signaling
ESCs	Ectoderm and/or endoderm lineage differentiation	Self-renewal	Mesoderm lineage differentiation	Not determined	Not determined
HSCs	Self-renewal	Proliferation	Not determined	Monocytic differentiation	Proliferation
MSCs	Chondrogenic differentiation	Not determined	Not determined	Not determined	Proliferation and osteogenic differentiation
NSCs	Proliferation and/or neuron differentiation	Astrocyte differentiation	Not determined	Not determined	Not determined
CSCs	Self-renewal and differentiation	Not determined	Not determined	Proliferation	Not determined