Stem Cells International / 2018 / Article / Fig 3

Research Article

STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation

Figure 3

Recombinant ESCs allowing Dox-inducible deletion of STAT3 (InSTAT3 KO) or pSTAT3 overexpression (InSTAT3 CA). (a) In pTRE-CreCh/pEF1aTetR-inducible STAT3 KO ESCs, mCherry was observed after 24 hours Dox induction, indicating that Cre was expressed and functioned to delete STAT3 in vitro. (b) In pTRE-STAT3 CA/pEF1aTetR-inducible STAT3 CA ESCs, GFP was expressed after 24 hours Dox induction, suggesting that STAT3 CA was expressed.

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