Research Article

STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation

Figure 5

STAT3 deletion may affect cardiomyocyte differentiation. (a) Deletion of STAT3 led to significant reduction in the expression of cardiac transcription factors when STAT3 was deleted from day 0 onwards of cardiomyocyte differentiation of ESCs, indicating that STAT3 is required for cardiomyocyte differentiation of ESCs. (b) Decreased expression of STAT3 and Actn2 following STAT3 deletion on D0. Number of EB clones used for qPCR was 30 EBs at each time point.
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