Review Article

Emerging Role of Histone Acetyltransferase in Stem Cells and Cancer

Table 1

HAT classification.

NomenclatureCellular localizationHistone and nonhistone

Type A HAT
p300/CBP family
CBP (KAT3A)NucleusNF-kappaB, c-myb, Foxo1, NCOA3, PCNA, KLF1, transcription factor MafG, IRF-2
p300 (KAT3B)NucleusH2A, H2B, H3, NF-kappaB, c-myc, p53, STAT3, β-catenin, Foxo1, AR, ALX1, SIRT2, HDAC1, BCL6, MTA1, XBP1 isoform 2, PCNA, MEF2D, ZBTB7B
GNAT family
KAT2H3, H2B
GCN5 (KAT2A)NucleusH3, H4, H2A, CDC6, CDK9,cyclin D1, cyclin E1 and E2F1, HDM2, PTEN, c-myc, TBX5, PLK4, CEBPB
pCAF (KAT2B)NucleusH3, H4, p53, CDK9, c-myc, Foxo1, AR, TBX5, PLK4, ACLY
ELP3 (KAT9)H4, H2A, H3
ATAT-1 (MEC-17)Cytosolα-Tubulin, cortactin
MYST family
Tip60 (KAT5)NucleusH4, H2A, ATM, TRRAP, E2F1, c-myc, NR1D2, FOXP3, RAN
KAT6
MOZ (KAT6A)NucleusH3, p53
MORF (KAT6B)Nucleus
HBO1 (KAT7)NucleusH3, H4
MOF (KAT8)NucleusH4, p53
Transcription factor complexes
TAF1/TBP (KAT4)NucleusH3 H4
TFIIIC90 (KAT12)NucleusH3
Nuclear receptor coactivators
SCR1 (KAT13)NucleusH3 H4
Camello family
CamelloPerinucleusH4
Type B HAT
HAT1 (KAT1)Nucleus/cytosolH3, H4, H2A
HAT4 (KAT4)CytosolH4 H2A