|
| Material | Crosslink chemistry | Effect on cell lineages |
|
Natural | Collagen I | pH-sensitive crosslinking Temperature Photopolymerization | Pluripotency [21] Neural [3] |
Gelatin | Photopolymerization Temperature Passive coating | Osteogenic [1, 22] Chondrogenesis [9] Pluripotency [23] Pancreatic [10] Retinal [24] |
Fibrin | Enzymatic crosslinking | Endoderm [25] Neural [26, 27] Osteogenic [28] |
Hyaluronic acid (HA) | Photopolymerization | Pluripotency [29, 30] Neural [2, 3] Retinal [24] |
Cell-derived ECMs/Matrigel | Thermosensitive crosslinking | Pluripotency [31, 32] Vascular [15, 33] Neural [4, 32] |
Chitosan | Photopolymerization | Vascular [34] Osteogenic [1] |
Agarose | Thermosensitive hydrogel | Vascular [35] |
Dextran | Photopolymerization | Vascular [20] |
Alginate | CaCl2 crosslinking Photopolymerization | Neural [2] Retinal [16] Primordial germ cells [36] Osteogenic [28] |
Chondroitin sulfate | Glutaraldehyde crosslinking | Retinal [24] |
Hydroxyapatite; calcium phosphate | Glutaraldehyde crosslinking Freeze-dried | Osteogenic [1, 28] |
RADA16-I/II | Self-assembling peptides | Vascular (cardiac) [37, 38] |
Synthetic | Poly(ethylene glycol) (PEG) | Photopolymerization | Neural [11ā14] Vascular [15, 39] |
Poly(L-lysine) (PLL) | Polyelectrolyte films EDC crosslinking | Germ lineages [29] |
Polycaprolactone (PCL) | Electrospinning | Neural [4, 5] Osteogenic [6] Chondrogenic [9] |
Polylactic acid (PLA) | Electrospinning | Definitive endoderm [40] |
Poly(lactic-co-glycolic acid) (PLGA) | Electrospinning Freeze-dried | Neural [7, 8] Pancreatic [10] |
N-Isopropylacrylamide gels (NIPAAm) | Thermosensitive hydrogel | Neural [11, 41] Pluripotency [42] |
|