Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

Table 1

Incidence of each calcium abnormality type in all CPVT CMs after adrenaline stimulation and the percentages of these arrhythmias abolished by either carvedilol or flecainide.

	OS	MP	AL	PA	LP	IP
CPVT CMs	25%	37%	11%	21%	4%	2%
Carvedilol	27%	63%	0%	19%	33%	100%
Flecainide	32%	51%	27%	20%	57%	67%

MP, LP, and IP type of abnormal transients were abolished quite well by both drugs, while flecainide was superior in abolishing AL-type abnormalities. Incidence of LP and IP abnormalities was, however, low in CPVT CMs; therefore, conclusions should be made with caution.