Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Figure 9

Parameter sensitivity analysis of the two-compartment model. To evaluate the sensitivity, the parameters are perturbed around their nominal values fitted in experiment A with cell data collected from two donors in two conditions: (a) MSCs obtained from a female donor of age 56 and (b) MSCs isolated from a 78-year-old male donor. The exhibited sensitivity is measured by the standard deviation of model outputs in 1000 simulations with randomly perturbed (between ±10%) parameter values using the one-at-a-time approach.

(a)

(b)