Review Article

The Potentials and Caveats of Mesenchymal Stromal Cell-Based Therapies in the Preterm Infant

Figure 1

Pathogenesis of BPD: BPD is the consequence of distortion of alveolar, mesenchymal, and vascular development mainly in the saccular stage. Central to the disease is the inflammatory response which is characterized by a disbalance of cytokines and growth factors, the influx of inflammatory cells, cell death induction, and surfactant inactivation. Distortion of mesenchymal progenitor cell function represents a key event in disease pathogenesis.