Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression
Luteolin-7-glucoside promotes human EpSC proliferation in vitro. Human EpSCs were treated with different concentrations of luteolin-7-glucoside (L7G) for 24 or 48 h (a) or treated with 1 μM L7G for 1-4 d (b), 24 h (d), or 48 h (c); cell proliferation was examined by MTT assay (a, b), BrdU incorporation assay (c), or immunofluorescence staining of Ki67 (d). Cell cycle distribution of EpSCs treated with 1 μM L7G for 24 h was detected by flow cytometry (e). . Data are shown as (). and , compared with cells without L7G treatment for the same period of time.
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