Stem Cells International / 2019 / Article / Fig 3

Review Article

The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells

Figure 3

Integration of the integrated endoplasmic reticulum stress response (IERSR), ubiquitin proteasome system (UPS), and autophagy in maintaining a pristine proteome. The IERSR activates transcription factors that govern the expression of ER homoeostasis, UPS, and autophagy genes. Autophagy and UPS in turn degrade signaling molecules activated by the IERSR and trim ER and mitochondria to help these organelles return to their normal size and composition once unfolded proteins are cleared.

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