Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function

Figure 2

Cend1 induces the p53-Cyclin D1-pRb signaling pathway resulting in cell cycle arrest at the G1/G0 phase of the cell cycle. Cend1 triggers p53 and its downstream effector p21, leading to pRb hypophosphorylation and withdrawal from the cell cycle at the G1/G0 transition, while interfering with Cyclin D1 signaling.