Stem Cells International / 2019 / Article / Fig 2

Review Article

Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function

Figure 2

Cend1 induces the p53-Cyclin D1-pRb signaling pathway resulting in cell cycle arrest at the G1/G0 phase of the cell cycle. Cend1 triggers p53 and its downstream effector p21, leading to pRb hypophosphorylation and withdrawal from the cell cycle at the G1/G0 transition, while interfering with Cyclin D1 signaling.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.