Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling

<div>FDMSC exosomes activate the Notch signal pathway. (a, b) Western blot analysis of key Notch signaling-related protein levels in ADFs treated with SFM or exosomes. GAPDH served as a loading control. Notch1, Jagged 1, and Hes 1 were upregulated in ADF by exosome treatment. (c) Western blot analysis of Notch ligands in FDMSC exosomes. Jagged 1 is the only Notch ligand expressed in FDMSC exosomes while Jagged 2, Dll-1, Dll-3, and Dll-4 were undetectable. CD63 was used as a loading control of exosomes. 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Stem Cells International

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Figure 4

Figure 4: Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling 