Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells

<div>LY411575 inhibits <i>in vivo</i> ectopic bone formation. LY411575-treated hBMSCs and control hBMSCs were implanted with hydroxyl apatite/tricalcium phosphate (HA/TCP) subcutaneously into immune-deficient mice. The histology of in vivo bone formation was examined using H&amp;E (a) and Sirius red (b) staining. Black arrows in (a) indicate bone formation (magnification 10x), and black line shows the bone formed zone (magnification 20x). In Sirius red-stained slides (b), red color indicates collagen tissue staining. 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Stem Cells International

fig5

Figure 5

Figure 5: Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells 

Figure 5 | Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells 