Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance

Figure 2

Cellular fate mapping of MaSCs by lineage tracing in vivo. A simplified schematic depicts the existence of unipotent and multipotent MaSCs characterized with distinct cellular markers (embryonic MaSCs: K14+, Axin2+, Notch1, Blimp1+, and p63+; postnatal MaSCs for unipotent basal lineage: K14+, K5+, Lgr5+, Axin2+, p63+, and Acta2+; postnatal MaSCs for unipotent luminal lineage: K8+, Elf5, Prom1+, Notch1+, Notch3+, and Blimp1+; multipotent postnatal MaSCs: Axin2+, K5+, K14+, K19+, Lgr5+, Lgr6+, and Sox9+) and their distinct differentiations.